With their antioxidant, anti-inflammatory and anti-excitotoxic effects on central nervous system disease, it appears that cannabinoids are also able to delay ALS progression and prolong survival. [Sabrina Giacoppo and Emanuela Mazzon, Ph.D.; "Can Cannabinoids be a Potential Therapeutic Tool in Amyoptrophic Lateral Sclerosis?"; Neural Regeneration Research, December 2016; US National Library of Medicine National Institute of Health] 

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In addition to possibly helping with pain and increasing appetite, CBD may have a therapeutic calming effect on people presenting with agitation from Alzheimer's disease and other dementias. [Jennifer Palisoc; "Synthetic Cannabinoid Shows Calming Effect in Treating Agitation in Alzheimer's Patients"; Dr. Krista Lanctot, principal investigator; Sunnybrook Health Sciences Centre; July 24, 2018]

Cannabinoids can help regulate the immune system and suppress inflammatory responses and decrease joint-tissue injury in cases of rheumatoid arthritis and osteoarthritis. [Prakash Nagarkatti, Rupal Pandey, Sadiye Amcaoglu Rieder, Venkatesh L. Hegde, and Mitzi Nagarkatti; "Cannabinoids as Novel Anti-inflammatory Drugs; Future Medicinal Chemistry, October 2009; U.S. National Library of Medicine National Institute of Health]

Nausea is a difficult symptom to control, but laboratory investigations have shown that CBD may be an effective agent in its suppression and treatment. [Linda A Parker, Erin M Rock, and Cheryl L Limebeer; "Regulation of Nausea and Vomiting by Cannabinoids"; British Journal of Pharmacology; August 2011; U.S. National Library of Medicine National Institute of Health]

Medicinal Cannabis may be effective in interrupting and decreasing pain levels, and improving functional, social and emotional wellbeing. [Simon Haroutounian, Yael Ratz, Yehuda Ginosar, Karina Furmanov, Fayez Saifi, Ronit Meidan, Elyad Davidson; "The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study"; Clinical Journal of Pain; December 2016; U.S. National Library of Medicine National Institute of Health]

Despite its anti-inflammatory properties, Cannabis oil has no effect on gut inflammation; however, clinical studies show that it significantly improves the symptoms of Crohn's disease and quality of life. [Luke Paskins, Spink Health; "Cannabis Improves Symptoms of Crohn's Disease Despite Having No Effect on Gut Inflammation"; October 21, 2018; EurekaAlert/AAAS]

Many people across all walks of life experience sometimes debilitating depression. CBD offers great potential as an antidepressant-like compound, and has exhibited good results in animal studies. [Alexandre R de Mello Schier, Natalia P de Oliveira Ribeiro, Danielle S Coutinho, Sergio Machado, Oscar Arias-Carrión, Jose A Crippa, Antonio W Zuardi, Antonio E Nardi, Adriana C Silva; "Antidepressant-like and Anxiolytic-like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa"; 2014; NIH National Library of Medicine; National Center for Biotechnology Information; PubMed.gov]

Research on CBD's efficacy for controlling epileptic seizures suggests cannabinoids may reduce seizure frequency and severity without producing euphoric or intrusive side effects. [Emily Stockings, Dino Zagic, Gabrielle Campbell, Megan Weier, Wayne D Hall, Suzanne Nielsen, Geoffrey K Herkes, Michael Farrell, Louisa Degenhardt; "Evidence for Cannabis and Cannabinoids for Epilepsy: A Systematic Review of Controlled and Observational Evidence"; BMJ Journals - Journal of Neurology, Neurosurgery & Psychiatry, October, 2017]

CBD has shown promising results in the treatment of intractable (uncontrolled or refractory) epilepsy, particularly in the pediatric epilepsy populations. Benefits other than seizure control included improved sleep, alertness, mood, and language and motor skills. [Michal Tzadok, Shimrit Uliel-Siboni, Ilan Linder, Uri Kramer, Orna Epstein, Shay Menascu, Andrea Nissenkorn, Omer Bar Yosef, Eli Hyman, Dorit Granot, Michael Dor, Tali Lerman-Sagie, Bruria Ben-Zeev; "CBD-enriched Medical Cannabis for Intractable Pediatric Epilepsy: The Current Israeli Experience"; Science Direct, February, 2016]

People with fibromyalgia may find that medicinal cannabis can offer relief from a range of symptoms. In one study, consumers felt relaxed, enjoyed reduced pain and stiffness, and had an increased sense of wellbeing. [Jimena Fiz, Marta Durán, Dolors Capellá, Jordi Carbonell, Magi Farré; "Cannabis Use in Patients with Fibromyalgia: Effect on Symptoms Relief and Health-related Quality of Life"; PLOS ONE, April 21, 2011; NIH National Library of Medicine; National Center for Biotechnology Information; PubMed.gov]

Pain begs relief. Topically administered, selective cannabinoid agents may help control breakthrough pain, having demonstrated analgesic effects in animal models on inflammatory and neuropathic pain. [Liliana L Jorge, Caroline C Feres, Vitor EP Teles; "Topical Preparations for Pain Relief: Efficacy and Patient Adherence"; Dove Medical Press; Journal of Pain Research, December 20, 2010; NIH - US National Library of Medicine]

Research around the use of CBD in treating sleep disorders is still preliminary, but may suggest some therapeutic potential in providing relief from insomnia. [Kimberly A Babson, James Sottile, Danielle Morabito; "Cannabis, Cannabinoids, and Sleep: A Review of the Literature"; Current Psychiatry Reports, April 19, 2017; NIH National Library of Medicine; National Center for Biotechnology Information; PubMed.gov]

The therapeutic benefit of cannabis in the treatment of digestive disorders like IBS is actively being studied. It has been administered for symptoms such as abdominal pain and diarrhea. [Hemant Goyal, Umesh Singla, Urvashi Gupta, Elizabeth May; "Role of Cannabis in Digestive Disorders"; European Journal of Gastroenterology & Hepatology, February 2017;  Volume 29, Number 2]

For centuries physicians have used Cannabis in the prophylactic treatment of acute migraines. [Ethan Russo; "Cannabis for Migraine Treatment: the Once and Future Prescription? An Historical and Scientific Review"; Pain, Volume 76, Issues 1-2, May, 1998]

Influential scientific institutions report that cannabis may help ease sleep problems and the stiffness and muscle spasms common with MS. [Neil Lava, MD; Can Medical Marijuana Help Your MS?; WebMD, March 20, 2019]

As a therapeutic agent for the treatment of Parkinson's in Complementary Alternative Medicine (CAM), Cannabis was reported to help improve mood, sleep, motor symptoms and quality of life. [Taylor Andrew Finseth, Jessica Louise Hedeman, Robert Preston Brown, Kristina I Johnson, Matthew Sean Binder, Benzi M Kluger; "Self-Reported Efficacy of Cannabis and Other Complementary Medicine Modalities by Parkinson's Disease Patients in Colorado"; Hindawi; Evidence-Based Complementary and Alternative Medicine, March 2, 2015; Volume 2015]

Cannabinoids may help control PTSD sleep disturbances such as nightmares which are sometimes considered "treatment-resistant" with conventional medications. [George A Fraser, MD; "The Use of a Synthetic Cannabinoid in the Management of Treatment-Resistant Nightmares in Posttraumatic Stress Disorder (PTSD)"; CNS Neuroscience & Therapeutics February 13, 2009; Wiley Online Library]

Studies may suggest that CBD may have alerting properties, decrease stage 3 sleep, and increase awake activity during sleep. [Anthony N Nicholson, Claire Turner, Barbara M Stone, Philip J Robson; "Effect of Delta-9-tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults"; Journal of Clinical Psychopharmacology, June 2004]